Saturday, January 1, 2050

IVF in Stork Fertility Center (IVF in Taiwan)

What is IVF?

In Vitro Fertilization (IVF) is an assisted reproductive method wherein oocytes are fertilized by sperm outside of the womb, hence the word in vitro. It involves hormonally controlling ovulation stimulating increased follicle development, transvaginal oocyte retrieval and sperm collection, laboratory incubation for fertilization and zygote implantation into the uterus to establish pregnancy. After sperm retreival and successful fertilization, the embryo is implanted to the mother’s womb. This procedure is also known as Test Tube Baby.

(Know more IVF procedure at Stork Fertility Center)

(Know more donated programs at Stork Fertility Center)

(Know more oocyte-freezing programs at Stork Fertility Center)

Wednesday, May 24, 2017

Double stimulation (Duo-OPU)

 —  Continuous stimulation and oocyte retrieval during both the follicular and luteal phases of poor responders in IVF/ICSI programs can increase the obtained oocytes per menstrual cycle

Since the patients with diminished ovarian reserve could spend lots of time, energy, and money, on the multiple IVF treatments, the idea of double stimulation in a single cycle was developed. The following study is to compare the IVF outcomes obtained after single-stimulation (follicular phase stimulation) versus duoble stimulation (during both the follicular and luteal phases) in poor responders in IVF/ICSI programs.

Accordingly, it was believed that more than one follicular wave in a single menstrual cycle:

The retrospective study in Stork Fertility Center involved of total 388 oocytes from 79 patients in which the oocyte-donors were excluded during January to December, 2016. The total of 79 poor responders in IVF/ICSI programs (Bologna Criteria) underwent either duo-stimulation (45 cycles) or single-stimulation (156 cycles).

The mild stimulation 
or nature cycle protocols were used in both the groups,

All the embryos were cultured to blastocyst stage. For those need preimplantation genetic screening (PGS), the blastocysts were biopsied in Day 5 or Day 6. The applied method of PGS includes whole genome amplification following with NGS (Miseq®). The resulted copy number variation analysis was performed on BlueFuse Multi software.

According to the results, the obtained mature oocytes (MII oocytes) per cycle were significant higher in duo-stimulation group (mean 2.83) compare to single-stimulation group (mean 1.53) (p=0.001).

Our data also showed that no significant difference were observed between single-Stimulation and duo-Stimulation in MII rate (81.03%; 83.70%), fertilization rate (72.9%; 73.33%), good embryo rate (74.07%; 69.70%), good blastocyst rate (62.50%; 51.52%), and euploid rate (30.77%; 13.0%). (The data for the PGS in due-stimulation group was limited.)

In conclusion, duo-stimulation statistically significantly increasing the obtained oocytes per menstrual cycle compare to single-stimulation and resulted in similar IVF outcome in patients with reduced ovarian response. Our study suggests this novel stimulation strategy will help poor responders to collect more mature oocytes within a single menstrual cycle.

The abstract was released in the 2017, Asia Pacific Initiative on Reproduction annual congress. (2017 ASPIRE)

Sunday, May 14, 2017

Stork Fertility Center in Taiwan Chamber of Commerce in Canada

During May 1st to 3rd in 2017, Taiwan Chamber of Commerce in Canada (TCCCA) hold "2017 Taiwan Medical Services Orientation" in couple of places in Canada, introducing more facets of Taiwan medical techniques to the local expatriates whose original language are Chinese. The Taiwanese representatives were from aesthetic or cosmetic medical center, dental department, health evaluation center, ophthalmology department, and fertility center. Stork Fertility Center was the only delegate of infertility, showing the patient-friendly program designadvanced assisted reproductive techniques and competitive prices to the people in Toronto, Montreal, and Vancouver.

Monday, April 24, 2017

The best is yet to come

She was always gentle to the medical team.

Behind the smiling face,

We all knew the disappointments and frustration.

In the past six months,

No embryos were available for transfer.

A woman is born with a limited number of oocytes which gradually diminishes by age. It is an irreversible process. As the maternal age increases, both the quantity and quality of the oocytes decrease. Accordingly, the live birth rate in women over 40 years is under 10%, since the aneuploid rate of oocyte is quite high.

Monday, April 17, 2017

I feel bloated—ovarian hyperstimulation syndromes (OHSS)

Ms. Helen started appointments with me since last year. She has been married for two years without preventing pregnancy, but still no good news released. By several examinations, I found that she has some features of polycystic ovarian syndromes.